The crash happened at 7:51 a.m. on county road W-40 in rural Winneshiek County Iowa, south of Hesper.
According to the Iowa state patrol, an Oldsmobile sedan going north lost control and slid into an oncoming Ford pickup truck.
17-year-old Avery Arneson and 13-year-old Aden Arneson died at the scene.
Responders took three other teens in the car to hospitals in serious condition.
The 15-year-old truck driver was also hospitalized, but his injuries are not said to be serious.
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